Journal & Article

Biochemistry & Molecular Biology

I/F
# Journal I/F

Signal Transduction and Targeted Therapy

Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases. Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies. Revitalizing T cells: breakthroughs and challenges in overcoming T cell exhaustion. Ubiquitination at pericentromeric regions: directing heterochromatin reassembly during cell division. Antiviral drug discovery and development: challenges and future directions. In defence of ferroptosis Correction to: CD4 T cell contact drives macrophage cell cycle G0-G1 transition (Signal Transduction and Targeted Therapy, (2024), 9, 1, (348), 10.1038/s41392-024-02053-2) Radiopharmaceuticals and their applications in medicine Islet environment and development of type 1 diabetes in the biobreeding rat model Both inhibitory and activating KIRs recognize RIFINs: a dual-edged mechanism of NK cell control in malaria. Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut. Towards biomarker-driven cancer immunotherapy: the rising of a protein phosphatase regulator. The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer. EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors Pandemic punch: SARS-CoV-2 hits pancreas Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside Intratumoural microbiota: a new frontier in cancer development and therapy Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets AKT2S128/CCTαS315/319/323-positive cancer-associated fibroblasts (CAFs) mediate focal adhesion kinase (FAK) inhibitors resistance via secreting phosphatidylcholines (PCs) PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study DNA framework signal amplification platform-based high-throughput systemic immune monitoring Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia: a prospective, single arm, phase I trial The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses Major depressive disorder: hypothesis, mechanism, prevention and treatment Infection with SARS-CoV-2 can cause pancreatic impairment TGF-β signaling in health, disease, and therapeutics Metabolic memory: mechanisms and diseases New clinical trial design in precision medicine: discovery, development and direction Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled Correction: The Hippo signalling pathway and its implications in human health and diseases (Signal Transduction and Targeted Therapy, (2022), 7, 1, (376), 10.1038/s41392-022-01191-9) Tripartite motif-containing protein 11 (TRIM11): a novel weapon against Alzheimer’s disease Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis Cholesterol business: life or death by rust Correction: Signaling pathways and targeted therapies for psoriasis (Signal Transduction and Targeted Therapy, (2023), 8, 1, (437), 10.1038/s41392-023-01655-6) Correction: Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine (Signal Transduction and Targeted Therapy, (2023), 8, 1, (462), 10.1038/s41392-023-01718-8) NF-κB in biology and targeted therapy: new insights and translational implications Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity Diabetes and pulmonary infection: how hyperglycaemia shapes the immune system The two sides of chromosomal instability: drivers and brakes in cancer Harnessing innate immune pathways for therapeutic advancement in cancer Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets Correction: BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis (Signal Transduction and Targeted Therapy, (2023), 8, 1, (271), 10.1038/s41392-023-01478-5) QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study Discovering deaminases using AlphaFold2: a strategy to search for tool proteins for gene editing Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment