3 Questions: Using AI to accelerate the discovery and design of therapeutic drugs

Professor James Collins discusses how collaboration has been central to his research into combining computational predictions with new experimental platforms.

MIT News 3 Questions: Using AI to accelerate the discovery and design of therapeutic drugs

AlphaGenome Deciphers Non-Coding DNA for Gene Regulation

When AlphaFold solved the protein-folding problem in 2020, it showed that artificial intelligence could crack one of biology’s deepest mysteries: how a string of amino acids folds itself into a working molecular machine.The team at Google DeepMind behind that Nobel Prize-winning platform then turned their lens from from the structure of proteins to how these molecules function in the body. Applying similar machine-learning methods, they first developed AlphaMissense, an AI tool for predicting which changes in protein structure are likely to cause disease. AlphaProteo, a system for designing proteins that bind to specific molecular targets, came next.Now the architects of the Alpha platform..

IEEE Spectrum > Artificial Intelligence

From guardrails to governance: A CEO’s guide for securing agentic systems

The previous article in this series, “Rules fail at the prompt, succeed at the boundary,” focused on the first AI-orchestrated espionage campaign and the failure of prompt-level control. This article is the prescription. The question every CEO is now getting from their board is some version of: What do we do about agent risk? Across…

MIT Technology Review From guardrails to governance: A CEO’s guide for securing agentic systems