Issue Information. Editorial: Factualities – establishing empirical truths in child psychology and psychiatry. Issue Information. Editorial: Money cannot buy happiness - but can it prevent depression? A commentary on Su etal. Issue Information. Editorial: COVID-19: lessons learned for suicide prevention. Issue Information. Issue Information. Editorial: Is there a core deficit in specific learning disabilities? Issue Information. Editorial: 'In our time': Has the pandemic changed the way we write and read mental health and neurodevelopmental disorder research reviews? Commentary: Deepening understanding of refugee children and adolescents using Bronfenbrenner's bioecological and PPCT models - A Commentary on Arakelyan and Ager (2020). Annual Research Review: Achieving universal health coverage for young children with autism spectrum disorder in low- and middle-income countries: a review of reviews. Annual Research Review: Youth firearm violence disparities in the United States and implications for prevention. Commentary: Let's get digital: a commentary on Halldorsson et al.'s call for more rigorous development and evaluation of immersive digital interventions for children and young people's mental health. Commentary: The critical role of oral language deficits in reading disorders: reflections on Snowling and Hulme (2021). Commentary: Schizophrenia prevention and prodromal psychosis in children and adolescents. Issue Information. Editorial: 'The early bird catches the worm'-the need for even earlier intervention and targeted prevention for mental illnesses. Issue Information. Editorial: Standardizing methods and measures in randomized controlled trials: a necessary catalyst for clinical translation. Issue Information. Editorial: Is child mental health research structurally racist? Issue Information. "School of hard knocks" - what can mental health researchers learn from the COVID-19 crisis? Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders. Associations between physiological and neural measures of sensory reactivity in youth with autism. Prospective impact of COVID-19 on mental health functioning in adolescents with and without ADHD: protective role of emotion regulation abilities. Developmental differences in neural connectivity for semantic processing in youths with autism. Practitioner Review: Parenting interventions for child conduct problems: reconceptualising resistance to change. Adaptive intervention for prevention of adolescent suicidal behavior after hospitalization: a pilot sequential multiple assignment randomized trial. Moderators of response to child-based and parent-based child anxiety treatment: a machine learning-based analysis. Executive function mediates the prospective association between neurostructural differences within the central executive network and anti-social behavior after childhood traumatic brain injury. Childhood psychopathology mediates associations between childhood adversities and multiple health risk behaviours in adolescence: analysis using the ALSPAC birth cohort. Commentary: Does 'cry it out' really have no adverse effects on attachment? Reflections on Bilgin and Wolke (2020). No evidence for a core deficit in developmental dyscalculia or mathematical learning disabilities. Commentary: On intimate relationships, adult roles, interplay of family adversity and individual vulnerability, intergenerational transmission, and developmental selection - commentary on Vergunst et al. (2020). Immersive virtual reality and digital applied gaming interventions for the treatment of mental health problems in children and young people: the need for rigorous treatment development and clinical evaluation. Examining the bidirectional association between emotion recognition and social autistic traits using observational and genetic analyses. A scalable computational approach to assessing response to name in toddlers with autism. Impact of language disorders on children's everyday lives from 4 to 13 years: Commentary on Le, Mensah, Eadie, McKean, Schiberras, Bavin, Reilly and Gold (2020). Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis. What does genetic research tell us about the origins of language and literacy development? A reflection on Verhoef et al. (2020). Commentary: Social Immune Processes as Pathways to Psychopathology: a commentary on Robles (2020). Brain activity during facial processing in autism spectrum disorder: an activation likelihood estimation (ALE) meta-analysis of neuroimaging studies. Identifying environmental pathways between irritability during childhood and suicidal ideation and attempt in adolescence: findings from a 20-year population-based study. Differential outcomes of tonic and phasic irritability in adolescent girls. Depicting the composition of gut microbiota in children with tic disorders: an exploratory study. Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021).